Arm, Leg, and Foot Skin Water in Persons With Diabetes Mellitus (DM) in Relation to HbA1c Assessed by Tissue Dielectric Constant (TDC) Technology Measured at 300 MHz
Identifieur interne : 001400 ( Main/Exploration ); précédent : 001399; suivant : 001401Arm, Leg, and Foot Skin Water in Persons With Diabetes Mellitus (DM) in Relation to HbA1c Assessed by Tissue Dielectric Constant (TDC) Technology Measured at 300 MHz
Auteurs : Harvey N. Mayrovitz [États-Unis] ; Irina Volosko [États-Unis] ; Bansari Sarkar [États-Unis] ; Naushira Pandya [États-Unis]Source :
- Journal of Diabetes Science and Technology [ 1932-2968 ] ; 2016.
Abstract
DM is associated with structural skin changes. However, few studies have investigated changes in dermal water and specifically its relationship to glucose control as measured by HbA1c. Our goal was to test the hypothesis that skin water, assessed by its tissue dielectric constant (TDC), is inversely related to HbA1c.
Water content of 3 skin sites (forearm, lower leg, and foot dorsum) of 50 persons with DM was estimated by measuring TDC at 300 MHz. TDC is the ratio of tissue dielectric constant to vacuum and depends on free and bound water in the measured volume. TDC was measured in triplicate to 4 depths, 0.5. 1.5, 2.5, and 5.0 mm to include different skin components.
At each site increased measurement depth showed (1) a significant decrease in absolute TDC values and (2) a significant increase in foot-to-arm TDC ratios. TDC values at forearm were shown to be greater than at either leg or foot. However, testing of these 50 patients at 3 sites and 4 skin depths did not show any significant relationship between TDC and HbA1c or fasting glucose.
The data indicate no relationship between TDC values, as indices for skin water, and HbA1c or fasting glucose. This implies that skin TDC values to assess skin property features and changes in persons with DM are not sensitive to recent glucose control. Furthermore, the results introduce a newly applied TDC technology useful to assess skin properties of persons with DM.
Url:
DOI: 10.1177/1932296816662284
PubMed: 27491529
PubMed Central: 5505408
Affiliations:
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Mayrovitz</name><affiliation wicri:level="1"><nlm:aff id="aff1-1932296816662284">Colleges of Medical Sciences and Osteopathic Medicine, Nova Southeastern University, Ft. Lauderdale, FL, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Colleges of Medical Sciences and Osteopathic Medicine, Nova Southeastern University, Ft. Lauderdale, FL</wicri:regionArea><wicri:noRegion>FL</wicri:noRegion></affiliation></author><author><name sortKey="Volosko, Irina" sort="Volosko, Irina" uniqKey="Volosko I" first="Irina" last="Volosko">Irina Volosko</name><affiliation wicri:level="1"><nlm:aff id="aff1-1932296816662284">Colleges of Medical Sciences and Osteopathic Medicine, Nova Southeastern University, Ft. Lauderdale, FL, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Colleges of Medical Sciences and Osteopathic Medicine, Nova Southeastern University, Ft. Lauderdale, FL</wicri:regionArea><wicri:noRegion>FL</wicri:noRegion></affiliation></author><author><name sortKey="Sarkar, Bansari" sort="Sarkar, Bansari" uniqKey="Sarkar B" first="Bansari" last="Sarkar">Bansari Sarkar</name><affiliation wicri:level="1"><nlm:aff id="aff1-1932296816662284">Colleges of Medical Sciences and Osteopathic Medicine, Nova Southeastern University, Ft. Lauderdale, FL, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Colleges of Medical Sciences and Osteopathic Medicine, Nova Southeastern University, Ft. Lauderdale, FL</wicri:regionArea><wicri:noRegion>FL</wicri:noRegion></affiliation></author><author><name sortKey="Pandya, Naushira" sort="Pandya, Naushira" uniqKey="Pandya N" first="Naushira" last="Pandya">Naushira Pandya</name><affiliation wicri:level="1"><nlm:aff id="aff1-1932296816662284">Colleges of Medical Sciences and Osteopathic Medicine, Nova Southeastern University, Ft. 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Our goal was to test the hypothesis that skin water, assessed by its tissue dielectric constant (TDC), is inversely related to HbA1c.</p></sec><sec id="section2-1932296816662284"><title>Methods:</title><p>Water content of 3 skin sites (forearm, lower leg, and foot dorsum) of 50 persons with DM was estimated by measuring TDC at 300 MHz. TDC is the ratio of tissue dielectric constant to vacuum and depends on free and bound water in the measured volume. TDC was measured in triplicate to 4 depths, 0.5. 1.5, 2.5, and 5.0 mm to include different skin components.</p></sec><sec id="section3-1932296816662284"><title>Results:</title><p>At each site increased measurement depth showed (1) a significant decrease in absolute TDC values and (2) a significant increase in foot-to-arm TDC ratios. TDC values at forearm were shown to be greater than at either leg or foot. However, testing of these 50 patients at 3 sites and 4 skin depths did not show any significant relationship between TDC and HbA1c or fasting glucose.</p></sec><sec id="section4-1932296816662284"><title>Conclusions:</title><p>The data indicate no relationship between TDC values, as indices for skin water, and HbA1c or fasting glucose. This implies that skin TDC values to assess skin property features and changes in persons with DM are not sensitive to recent glucose control. Furthermore, the results introduce a newly applied TDC technology useful to assess skin properties of persons with DM.</p></sec></div></front></TEI><affiliations><list><country><li>États-Unis</li></country></list><tree><country name="États-Unis"><noRegion><name sortKey="Mayrovitz, Harvey N" sort="Mayrovitz, Harvey N" uniqKey="Mayrovitz H" first="Harvey N." last="Mayrovitz">Harvey N. Mayrovitz</name></noRegion><name sortKey="Pandya, Naushira" sort="Pandya, Naushira" uniqKey="Pandya N" first="Naushira" last="Pandya">Naushira Pandya</name><name sortKey="Sarkar, Bansari" sort="Sarkar, Bansari" uniqKey="Sarkar B" first="Bansari" last="Sarkar">Bansari Sarkar</name><name sortKey="Volosko, Irina" sort="Volosko, Irina" uniqKey="Volosko I" first="Irina" last="Volosko">Irina Volosko</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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